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Mononeuritis multiplex in Waldenström's macroglobulinemia.
1Unit of Neuropathology, Hospital Nostra Senyora del Mar, Universitat Autonoma, Barcelona, Spain.
Annals of Neurology
|August 1, 1987
Summary
This study details a patient with Waldenström
Area of Science:
- Neurology
- Hematology
- Pathology
Background:
- Waldenström's macroglobulinemia is a rare lymphoproliferative disorder.
- Mononeuritis multiplex is a neurological condition affecting multiple individual nerves.
Observation:
- A patient presented with mononeuritis multiplex and cranial nerve palsies.
- The patient was diagnosed with Waldenström's macroglobulinemia.
Findings:
- Sural nerve biopsy revealed extensive endoneurial granulofibrillary deposits.
- Microangiopathic changes and multifocal fascicular distribution were noted.
- Immunohistochemistry confirmed the deposits were composed of IgM within the endoneurial interstitium.
Implications:
- This case highlights a potential link between Waldenström's macroglobulinemia and peripheral neuropathy.
- Understanding the deposition of IgM in nerve tissue is crucial for diagnosing and managing such cases.
- Further research may elucidate the pathogenic mechanisms of neuropathy in Waldenström's macroglobulinemia.