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Mononeuritis multiplex in Waldenström's macroglobulinemia.

J Lamarca¹, P Casquero, A Pou

¹Unit of Neuropathology, Hospital Nostra Senyora del Mar, Universitat Autonoma, Barcelona, Spain.

Annals of Neurology

|August 1, 1987

Summary

This study details a patient with Waldenström

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Area of Science:

Neurology
Hematology
Pathology

Background:

Waldenström's macroglobulinemia is a rare lymphoproliferative disorder.
Mononeuritis multiplex is a neurological condition affecting multiple individual nerves.

Observation:

A patient presented with mononeuritis multiplex and cranial nerve palsies.
The patient was diagnosed with Waldenström's macroglobulinemia.

Findings:

Sural nerve biopsy revealed extensive endoneurial granulofibrillary deposits.
Microangiopathic changes and multifocal fascicular distribution were noted.
Immunohistochemistry confirmed the deposits were composed of IgM within the endoneurial interstitium.

Implications:

This case highlights a potential link between Waldenström's macroglobulinemia and peripheral neuropathy.
Understanding the deposition of IgM in nerve tissue is crucial for diagnosing and managing such cases.
Further research may elucidate the pathogenic mechanisms of neuropathy in Waldenström's macroglobulinemia.

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