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Interaction of small molecules with polynucleotide repeats and frameshift site RNA

Mohamed T M Nemr¹, Mahmoud N M Yousif², Jan Barciszewski^3,4

¹Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Archiv Der Pharmazie

|June 7, 2019

Abstract:

This mini-review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA-associated diseases or detecting target molecules. In the case of RNA-associated disease treatment, the designed small molecules interact with RNA sites, forming adducts and providing successful therapeutic strategies over oligonucleotides. On the other hand, synthetically designed RNA moieties (aptamers) interact with target molecules like toxins, drugs, hormones; these interactions are useful in the detection, quantification or separation of these target moieties.

Keywords:

AIDS ALS DM1 FTD FXTAS RNA RNA-associated diseases aptamers interaction small molecules

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