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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Topical tacrolimus for allergic eye diseases.
Nir Erdinest1, Hadas Ben-Eli1,2, Abraham Solomon1
1Department of Ophthalmology, Hadassah-Hebrew University Medical Center.
Current Opinion in Allergy and Clinical Immunology
|June 7, 2019
Summary
Topical tacrolimus offers an effective treatment for chronic allergic eye diseases like vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC). This immunomodulator improves symptoms and prevents severe ocular complications, reducing the need for corticosteroids.
Area of Science:
- Ophthalmology
- Immunology
- Allergology
Background:
- Allergic eye diseases involve complex immunopathologies.
- Antiallergic drugs and corticosteroids have limitations in managing chronic conditions like VKC and AKC.
- Corticosteroids pose risks for ocular complications, especially in children with VKC.
Purpose of the Study:
- To review recent clinical experience with topical tacrolimus for chronic allergic eye diseases.
- To update on the management of severe allergic conjunctivitis.
- To highlight tacrolimus as an immunomodulator for T-cell mediated eye conditions.
Main Methods:
- Review of recent clinical studies and experience with topical tacrolimus.
- Analysis of treatment outcomes for various chronic allergic eye diseases.
- Evaluation of tacrolimus efficacy in different concentrations and disease forms.
Main Results:
- Topical tacrolimus significantly improves signs and symptoms of chronic allergic eye diseases.
- Low concentrations of topical tacrolimus are effective for VKC.
- Early treatment with topical tacrolimus prevents severe VKC complications like shield ulcers and limbal stem cell deficiency.
Conclusions:
- Topical tacrolimus has transformed the management of severe, chronic allergic eye diseases.
- It effectively minimizes the reliance on topical corticosteroids.
- Tacrolimus offers a safer and more effective therapeutic option for conditions like VKC and AKC.
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