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Updated: Jan 23, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Central retinal venous occlusion in a child with hyperhomocysteinemia: A case report
Zhengfeng Liu1, Xuemei Pan2, Wenjun Jiang3
1Shandong University of Traditional Chinese Medicine.
Rationale:
To report a rare case of 8-year-old girl patient with central retinal venous occlusion (CRVO) with hyperhomocysteinemia.
Patient Concerns:
The patient had a 2-year history on painless visual loss in the left eye.
Diagnoses:
All examination results were within normal limits except plasma homocysteine (HCY). Fluorescein angiography (FA) confirmed peripheral capillary non-perfusion (CNP) in the left eye, and OCT showed macular edema. The girl patient was diagnosed as CRVO.
Interventions:
Based on all of the test results, laser photocoagulation was performed at peripheral capillary non-perfusion (NP). Ranibizumab was injected into virtreous cavity to reduce the macular edema. Oral folic acid, vitamin B12, and vitamin B6 were performed to the girl.
Outcomes:
After 13 months, the girl visual acuity recovered to 20/100 in the left eye.
Lessons:
All eye examinations should be performed in young patients, and they should undergo treatments immediately after is diagnosed as CRVO.
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