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Dose-averaged LET calculation for proton track segments using microdosimetric Monte Carlo simulations.

A Bertolet1,2, A Baratto-Roldán2, S Barbieri3

  • 1Department of Radiation Oncology, Hospital of The University of Pennsylvania, Philadelphia, 19104, PA, USA.

Medical Physics
|June 7, 2019
PubMed
Summary

Researchers developed a reliable and efficient Monte Carlo (MC) simulation method for calculating dose-averaged linear energy transfer (LET) in proton therapy. This approach corrects issues with weighted sampling, ensuring accurate biological effect assessments.

Keywords:
Geant4-DNALETd calculationmicrodosimetryproton therapysampling method

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Area of Science:

  • Medical Physics
  • Radiation Biology
  • Computational Science

Background:

  • Proton therapy utilizes proton beams for cancer treatment, with Linear Energy Transfer (LET) being a critical factor in assessing biological effects.
  • Accurate calculation of dose-averaged LET is essential for optimizing proton therapy protocols.
  • Current microdosimetric Monte Carlo (MC) simulations face computational challenges with uniform sampling and potential inaccuracies with weighted sampling methods.

Purpose of the Study:

  • To address limitations in weighted sampling methods for MC simulations of proton therapy.
  • To propose and validate corrections for reliable dose-averaged LET calculations.
  • To enhance the computational efficiency of microdosimetric simulations for proton therapy.

Main Methods:

  • Simulated proton track structures using Geant4-DNA with both uniform and weighted sampling approaches.
  • Developed and applied corrections to the weighted sampling method to achieve results comparable to uniform sampling.
  • Introduced an additional MC approach to calculate the weighted mean of energy imparted per electronic collision for straggling distribution analysis.

Main Results:

  • Found agreement in dose-averaged LET values below (0.15 ± 0.05) keV/μm between corrected weighted and uniform sampling methods.
  • Demonstrated that corrected weighted sampling provides reliable dose-averaged LET calculations.
  • Analysis was performed for spherical sites (1 and 10 μm) and proton beams (2-90 MeV).

Conclusions:

  • A reliable and computationally efficient method for calculating track segment dose-averaged LET in proton therapy using MC simulations was established.
  • The proposed corrections ensure accurate straggling distribution characteristics.
  • The method is valid when proton stopping power remains constant along the track within the site.