Related Experiment Video
Updated: Jan 23, 2026

07:46
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 15, 2010
44.4K
Progress Toward Measles Elimination - Pakistan, 2000-2018.
MMWR. Morbidity and Mortality Weekly Report
|June 7, 2019
Summary
Pakistan made progress in measles vaccination coverage, but challenges remain. Increased efforts are needed to achieve measles elimination, focusing on higher vaccination rates and improved surveillance.
Area of Science:
- Public Health
- Epidemiology
- Vaccinology
Background:
- The World Health Organization (WHO) Eastern Mediterranean Region (EMR) committed to measles elimination in 1997, with this goal reiterated in the 2015 Eastern Mediterranean Vaccine Action Plan.
- Pakistan, a populous EMR country, plays a significant role in regional measles elimination efforts.
- A four-pronged strategy by the WHO Regional Office for the Eastern Mediterranean includes high vaccination coverage (MCV1 and MCV2), robust surveillance, and optimal case management.
Purpose of the Study:
- To assess progress and identify challenges in achieving measles elimination in Pakistan from 2000 to 2018.
- To evaluate vaccination coverage trends and measles incidence during the study period.
Main Methods:
- Analysis of estimated measles-containing vaccine (MCV) first dose (MCV1) and second dose (MCV2) coverage.
- Review of data from supplementary immunization activities (SIAs).
- Examination of reported confirmed measles incidence and suspected case investigation rates.
Main Results:
- MCV1 coverage increased from 57% in 2000 to 76% in 2017; MCV2 coverage rose from 30% in 2009 to 45% in 2017.
- Over 232 million children received MCV doses during SIAs between 2000 and 2018.
- Reported confirmed measles incidence significantly increased from 24.6 per million (2000-2009) to 80.4 per million (2010-2018), with notable peaks.
- Low rates of non-measles cases suggest underreporting of measles cases.
Conclusions:
- Despite progress in vaccination coverage, Pakistan faces substantial challenges in achieving measles elimination.
- Increased MCV1 and MCV2 coverage, targeted strategies for underserved communities, and enhanced surveillance sensitivity are crucial.
- Urgent, intensified efforts are required to meet regional measles elimination goals.
Related Concept Videos
Kinetics of Drug Elimination
4.1K
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is the half-life of a drug, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is the half-life of a drug, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
4.1K
Enhanced Elimination of Poison
878
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
878
Radical Formation: Elimination
2.3K
Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions with respect...
2.3K
Elimination Reactions
16.7K
A nucleophile can react with an alkyl halide to give the substitution product by displacing the halogen. Or it can function as a base to give the elimination product by deprotonation of the neighboring carbon to form an alkene. In an elimination reaction, the substrate loses two groups from adjacent carbons forming at least one π bond. The carbon attached to the halogen is called the α carbon, while the adjacent carbon is called the β carbon; hence, these reactions are called...
16.7K
Elimination Kinetics: First-Order and Zero-Order
2.8K
Eliminating drugs from the body is a vital process that occurs through excretion or metabolism. Understanding the kinetics of drug elimination is crucial for drug development, dosage determination, and optimizing patient outcomes.
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
2.8K
Tumor Progression
7.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.3K

