Related Experiment Video

Updated: Jan 23, 2026

Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics
08:29

Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics

Published on: November 27, 2017

20.3K

Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

Christina L Burnett1, Ivan Boyer2, Wilma F Bergfeld3

  • 11 Cosmetic Ingredient Review Scientific Analyst/Writer, Cosmetic Ingredient Review, Washington, DC, USA.

International Journal of Toxicology
|June 8, 2019
PubMed

Insights

Methylisothiazolinone (MI) is safe as a cosmetic preservative. It is approved for rinse-off products up to 100 ppm and for leave-on products if formulated to be non-sensitizing.

Area of Science:

  • Cosmetic Science
  • Dermatology
  • Toxicology

Background:

  • Methylisothiazolinone (MI) is a widely used preservative in cosmetics.
  • Previous safety assessments have informed its use.
  • Concerns regarding skin sensitization necessitate ongoing review.

Purpose of the Study:

  • To evaluate the safety of methylisothiazolinone (MI) in cosmetic products.
  • To determine safe concentration limits for MI in different product types.
  • To establish criteria for the safe use of MI in leave-on formulations.

Main Methods:

  • Review of existing animal and human safety data for methylisothiazolinone (MI).
  • Analysis of data from previous safety assessments.
  • Consideration of quantitative risk assessment for non-sensitizing formulations.

Main Results:

  • Methylisothiazolinone (MI) is deemed safe for rinse-off cosmetic products at concentrations up to 100 ppm.
  • MI is considered safe for leave-on cosmetic products when formulated to be non-sensitizing.
  • Quantitative risk assessment can determine acceptable non-sensitizing formulations.

Conclusions:

  • The Cosmetic Ingredient Review Expert Panel concludes methylisothiazolinone (MI) is safe under specified conditions.
  • Safe use of MI in rinse-off products is established up to 100 ppm.
  • Safe use of MI in leave-on products depends on formulation to prevent sensitization.
Keywords:
cosmeticsmethylisothiazolinonesafety

More Related Videos

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques07:05

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Published on: August 23, 2024

2.8K
Monitoring Pedogenic Inorganic Carbon Accumulation Due to Weathering of Amended Silicate Minerals in Agricultural Soils.07:32

Monitoring Pedogenic Inorganic Carbon Accumulation Due to Weathering of Amended Silicate Minerals in Agricultural Soils.

Published on: June 4, 2021

5.7K

Related Concept Videos

Survey Safety01:28

Survey Safety

Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
380
Household Wiring And Electrical Safety01:13

Household Wiring And Electrical Safety

Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.6K
Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
1.1K
Nursing Assessment01:29

Nursing Assessment

The two sources for collecting information are primary and secondary. After gathering information, interpretation and validation help to complete the data. The purpose of assessment is to establish data with the initial information, to interpret data about the patient's perceived needs and health problems, and to respond to these problems identified.
The nurse collects all aspects of the patient's health in the initial assessment, establishing priorities for ongoing focused assessments...
9.2K
Assessment of Respiration01:23

Assessment of Respiration

The respiratory system's basic structures and primary functions lay the foundation for nurses' comprehensive respiratory assessments. This assessment includes subjective and objective data to gauge the patient's respiratory health.
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like...
1.9K
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
1.2K