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Updated: Jan 23, 2026

Zika Virus Specific Diagnostic Epitope Discovery
Published on: December 12, 2017
Performance evaluation of the Diasorin LIAISON® XL Zika capture IgM CLIA test
Y Van der Beken1, D De Geyter2, M Van Esbroeck3
1National Reference Center for Arboviruses, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium; Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel, Department of Microbiology, Brussels, Belgium.
Abstract:
Because Zika virus (ZIKV) can cause serious birth defects and is involved in cases of Guillain-Barré syndrome, the ZIKV outbreak in the American continent in 2015 resulted in an enormous need for ZIKV diagnostic tools. We evaluated the LIAISON® XL Zika Capture IgM test on 106 samples from patients, mainly travelers, with a confirmed or probable ZIKV infection. Sensitivity between 0 and 84 days after onset of symptoms was 92.5%. Specificity was evaluated on a panel of 56 samples known to cause possible cross-reactions. Cross-reaction with DENV antibodies was limited (10.5%) but false-positive results occurred in samples from patients with malaria, CMV and EBV infections.
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