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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
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Association of Autoimmune Hepatitis and Cardiovascular Disease

Alana Persaud1, Ahmed Ahmed1, Gaurav Kakked2

  • 1Division of Medicine, Rutgers New Jersey Medical School, USA.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|June 8, 2019
PubMed

Insights

Cardiovascular disease (CVD) is not associated with Autoimmune Hepatitis (AIH). This study found a decreased association between AIH and CVD, including coronary artery and peripheral vascular disease.

Area of Science:

  • Hepatology
  • Cardiology
  • Epidemiology

Background:

  • Autoimmune Hepatitis (AIH) is a chronic liver condition.
  • Cardiovascular Disease (CVD) is often observed in inflammatory conditions.

Purpose of the Study:

  • To investigate the association between Autoimmune Hepatitis and Cardiovascular Disease.
  • To evaluate the hospital burden associated with Cardiovascular Disease in AIH patients.

Main Methods:

  • Utilized the National Inpatient Sample database for 2014.
  • Included patients with a primary diagnosis of Autoimmune Hepatitis and secondary diagnosis of Cardiovascular Disease.
  • Analyzed the association between AIH and CVD, including specific conditions like Coronary Artery Disease and Peripheral Vascular Disease.

Main Results:

  • A decreased association was observed between Autoimmune Hepatitis and Cardiovascular Disease (aOR 0.77).
  • This inverse relationship extended to Coronary Artery Disease (aOR 0.75) and Peripheral Vascular Disease (aOR 0.75).
  • Coronary Artery Disease, comprising 84% of the CVD cohort, did not significantly increase length of stay or hospitalization costs.

Conclusions:

  • The reduced association between Autoimmune Hepatitis and Cardiovascular Disease may be multifactorial.
  • Further prospective studies are warranted to explore this complex relationship.
Abstract

Keywords:
Autoimmune hepatitisCoronary artery diseaseHospital burden

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