Related Experiment Video

Updated: Jan 23, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K

Antiplatelet Therapy in Patients with Aneurysmal SAH: Impact on Delayed Cerebral Ischemia and Clinical Outcome. A

F Cagnazzo1, I Derraz2, P-H Lefevre2

  • 1From the Neuroradiology Department (F.C., I.D., P.-H.L., G.G., C.D., C.R., A.B., V.C.), University Hospital Güi-de-Chauliac, Centre Hospitalier Universitaire de Montpellier, Montpellier, France f.cagnazzo86@gmail.com.

AJNR. American Journal of Neuroradiology
|June 8, 2019
PubMed

Insights

Antiplatelet therapy did not significantly reduce delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (SAH). However, it was associated with improved outcomes and lower mortality rates in SAH patients.

Area of Science:

  • Neurosurgery
  • Neurology
  • Clinical Trials

Background:

  • Delayed cerebral ischemia (DCI) is a major complication after aneurysmal subarachnoid hemorrhage (SAH), significantly impacting patient outcomes.
  • The role of antiplatelet therapy (APT) in mitigating DCI after SAH remains controversial, with existing studies reporting heterogeneous results.

Purpose of the Study:

  • To systematically evaluate the efficacy of antiplatelet therapy in reducing the incidence of DCI and improving clinical outcomes in patients following aneurysmal SAH.

Main Methods:

  • A systematic literature search was conducted across three databases for studies published between 1990 and 2019.
  • Random-effects meta-analysis was employed to synthesize data from eligible studies, comparing DCI rates, mortality, and good outcome rates between SAH patients with and without APT.

Main Results:

  • The meta-analysis included 7 studies with 1060 patients receiving APT and 1762 controls. Overall, APT did not significantly decrease DCI rates (OR=0.781, P=.33).
  • A trend towards lower DCI rates was observed in patients treated endovascularly with APT (OR=0.552, P=.06) and with long-term APT (>2 weeks) (OR=0.379, P=.06).
  • Significantly higher good outcome rates (OR=1.368, P=.002) and lower mortality rates (OR=0.656, P=.01) were associated with APT use.

Conclusions:

  • While overall DCI incidence was not significantly reduced by APT, trends suggest potential benefits in specific subgroups (endovascular treatment, long-term use).
  • Antiplatelet therapy demonstrated a significant association with improved clinical outcomes and reduced mortality in patients with aneurysmal SAH.
Abstract

More Related Videos

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment18:50

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment

Published on: September 25, 2009

14.0K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.4K

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
319
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.4K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.8K
Impact of Groups on Groups01:19

Impact of Groups on Groups

Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
236
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
106.8K
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
384