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A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
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Depletion of Specific Cell Populations by Complement Depletion
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[New Complement Therapeutics in Complement-Related Diseases].

Nobutaka Wakamiya1, Katsuki Ohtani, Yoshihiko Hidaka

  • 1Department of Medicine and Physiology, Rakuno Gakuen University.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|June 8, 2019
PubMed
Summary

The complement system, once thought only for immunity, is now known to drive diseases. Approved drugs like eculizumab target this system, spurring new therapeutic development.

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Area of Science:

  • Immunology
  • Pharmacology

Background:

  • The complement system, a part of innate immunity, supports antibody functions.
  • Initially recognized for microbial defense, its role in various disease pathologies is now understood.
  • The development of complement therapeutics has become a significant focus in pharmaceutical research.

Purpose of the Study:

  • To provide an overview of currently approved complement therapeutics.
  • To outline complement therapeutics currently in development and clinical trials.

Main Methods:

  • Review of approved drugs targeting the complement system.
  • Survey of ongoing clinical trials for novel complement-targeting therapies.

Main Results:

  • Eculizumab (anti-C5 antibody) approved for paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
  • Significant investment by pharmaceutical companies in developing new complement-based drugs.
  • Numerous complement therapeutics are progressing through various clinical trial phases.

Conclusions:

  • The complement system is a validated therapeutic target for various diseases beyond infections.
  • The success of eculizumab has catalyzed a new era of complement-targeted drug development.
  • Ongoing research and clinical trials indicate a promising future for complement therapeutics.