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The role of magnesium in different inflammatory diseases

Abbas Shahi1,2,3, Saeed Aslani1, MohammadReza Ataollahi4

  • 1Rheumatology Research Center, Tehran University of Medical Sciences, P.O.Box: 14117-13137, Tehran, Iran.

Inflammopharmacology
|June 8, 2019
PubMed

Insights

Magnesium deficiency triggers inflammation through various cellular pathways and stress responses. This review highlights magnesium

Area of Science:

  • Biochemistry
  • Immunology
  • Pathophysiology

Background:

  • Magnesium deficiency (MgD) is linked to inflammation.
  • MgD activates phagocytic cells, calcium channels, NMDA receptors, and NF-κB.
  • MgD induces systemic stress via neuroendocrinological pathways.

Purpose of the Study:

  • To review inflammatory diseases where magnesium plays a role in pathophysiology.
  • To highlight specific conditions including diabetes, asthma, preeclampsia, atherosclerosis, heart damage, and rheumatoid arthritis.

Main Methods:

  • Literature review of clinical trials and laboratory studies.
  • Analysis of the functional role of magnesium in inflammatory processes.

Main Results:

  • MgD contributes to pro-atherogenic lipoprotein metabolism.
  • Endothelial dysfunction and hypertension are associated with MgD.
  • Magnesium's role in inflammatory disease pathophysiology is supported by existing research.

Conclusions:

  • Magnesium is implicated in the pathophysiology of several inflammatory diseases.
  • Understanding magnesium's role can inform disease management strategies.
  • Further research into magnesium's functional role is warranted.
Keywords:
AsthmaAutoimmunityInflammationMagnesiumMagnesium deficiency

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