Related Experiment Video

Updated: Jan 23, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.5K

A Novel Modified System of Simplified Chinese Criteria for Familial Hypercholesterolemia (SCCFH)

Ye-Xuan Cao1, Di Sun1, Hui-Hui Liu1

  • 1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China.

Molecular Diagnosis & Therapy
|June 8, 2019
PubMed

Insights

Simplified Chinese Criteria for Familial Hypercholesterolemia (SCCFH) offers a simpler, effective method for diagnosing FH and preventing early coronary artery disease (CAD). This new system demonstrates high accuracy and ease of clinical use.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Genetics
  • Diagnostic Criteria Development

Background:

  • Familial hypercholesterolemia (FH) is a significant risk factor for early-onset coronary artery disease (CAD).
  • Existing diagnostic algorithms for FH are complex and often hindered by difficulties in obtaining family history information.
  • There is a need for a more accessible and efficient diagnostic system for FH.

Purpose of the Study:

  • To develop and validate a novel system of Simplified Chinese Criteria for FH (SCCFH).
  • To evaluate the diagnostic performance of SCCFH compared to established criteria like the Dutch Lipid Clinic Network (DLCN) and Simon Broome (SB) criteria.

Main Methods:

  • Recruited 12,921 participants for routine blood collection and clinical data acquisition.
  • Utilized clinical characteristics, laboratory results, and genetic testing for FH diagnosis.
  • Assessed the sensitivity, specificity, and agreement of SCCFH against DLCN and SB criteria.

Main Results:

  • Prevalence of definite FH was 1.73% (DLCN), 1.56% (SB), and 1.59% (SCCFH) among 12,921 participants.
  • SCCFH demonstrated high sensitivity (91.9% vs DLCN, 100% vs SB) and specificity (100% vs DLCN, 99.9% vs SB).
  • SCCFH showed excellent agreement with both DLCN (κ=0.958) and SB (κ=0.993) criteria, consistent across subgroups.

Conclusions:

  • The SCCFH system is a clinically practical tool comparable to existing criteria for diagnosing FH.
  • SCCFH offers high sensitivity and specificity, simplifying clinical application.
  • Further prospective studies are recommended to confirm the feasibility and reliability of SCCFH.
Abstract

More Related Videos

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.0K
Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

27.8K

Related Concept Videos

Protein Families02:47

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
16.7K
Protein Families02:47

Protein Families

4.3K
Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
9.9K
Gene Families01:57

Gene Families

3.6K
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
1.2K
Criteria for Causality: Bradford Hill Criteria - I01:30

Criteria for Causality: Bradford Hill Criteria - I

The Bradford Hill criteria are a group of principles that provide a framework to determine a causal relationship between a specific factor and a disease. There are nine criteria that are pivotal in assessing causality in epidemiological studies. Here's a closer look at Strength, Consistency, Specificity, and Temporality criteria with definitions and examples:
1.1K