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Gastrointestinal Complications in Chronic Granulomatous Disease

E Liana Falcone1, Steven M Holland2

  • 1Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. Emilia.falcone@nih.gov.

Methods in Molecular Biology (Clifton, N.J.)
|June 8, 2019
PubMed

Insights

Chronic granulomatous disease (CGD) patients often experience gastrointestinal inflammation, posing treatment challenges. Understanding the role of NOX2-derived ROS in inflammatory bowel disease may offer new therapeutic targets for CGD-associated GI issues.

Area of Science:

  • Immunology
  • Gastroenterology
  • Genetics

Background:

  • Chronic granulomatous disease (CGD) frequently involves gastrointestinal (GI) inflammation, impacting nearly half of affected patients.
  • The pathogenesis of CGD-associated GI inflammation is complex and multifactorial, complicating management.
  • Current treatment strategies face challenges due to the chronic nature of the inflammation and the need to balance immunomodulation with infection risk.

Purpose of the Study:

  • To review the clinical presentation, pathogenesis, and current management of CGD-associated GI inflammation.
  • To provide context for future therapeutic interventions.
  • To highlight the potential of understanding NOX2-derived ROS in IBD for CGD treatment.

Main Methods:

  • Literature review of clinical presentation, pathogenesis, and management of CGD-associated GI inflammation.
  • Analysis of the role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex 2 (NOX2)-derived reactive oxygen species (ROS).
  • Exploration of connections between inflammatory bowel disease (IBD) pathogenesis and CGD.

Main Results:

  • CGD-associated GI inflammation is a significant clinical issue with complex pathogenesis.
  • Management requires careful balancing of immunomodulation and infection risk.
  • The role of NOX2-derived ROS in IBD pathogenesis is increasingly understood.

Conclusions:

  • A comprehensive understanding of CGD-associated GI inflammation is crucial for developing effective treatments.
  • Investigating NOX2-derived ROS pathways may unveil novel therapeutic targets.
  • Further research into the interplay between NOX2, ROS, and inflammation in CGD is warranted.

Keywords:
Chronic granulomatous diseaseInflammatory bowel diseaseMicrobiomeNADPH oxidaseNOX2Reactive oxygen species

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