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Related Concept Videos

Translation01:31

Translation

155.9K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
155.9K
Translation01:31

Translation

17.7K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
17.7K
Initiation of Translation02:33

Initiation of Translation

38.4K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
38.4K
Termination of Translation01:44

Termination of Translation

27.5K
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
27.5K
Termination of Translation01:44

Termination of Translation

6.6K
6.6K
Improving Translational Accuracy02:07

Improving Translational Accuracy

14.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.1K

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Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
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Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

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Transradial access: A case for knowledge translation.

Jorge A Belardi1, Pablo M Lamelas1,2

  • 1Department of Interventional Cardiology and Endovascular Therapeutics, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|June 8, 2019
PubMed
Summary
This summary is machine-generated.

Current transradial access (TRA) practices are not well-documented globally. Key findings show declining collateral assessment, limited ultrasound use, and infrequent radial artery patency checks, highlighting significant knowledge gaps in TRA.

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Area of Science:

  • Cardiology
  • Vascular Interventions

Background:

  • Transradial access (TRA) is a minimally invasive technique for vascular procedures.
  • Current global practices and adherence to established guidelines for TRA are not well-understood.

Discussion:

  • A notable decline in preprocedure collateral assessment has been observed.
  • There is low utilization of ultrasound for guiding TRA.
  • Radial artery patency checks post-hemostasis are infrequent.

Key Insights:

  • Significant knowledge-practice gaps exist in the current application of TRA.
  • Suboptimal adherence to best practices may impact patient outcomes and procedural success.

Outlook:

  • There is a critical need for increased dissemination of best practices in TRA.
  • Further education and training initiatives are required to improve TRA implementation worldwide.