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Movement Retraining using Real-time Feedback of Performance
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Biomechanical Feedback Strengthens Jammed Cellular Packings.

Pawel Gniewek1, Carl F Schreck1, Oskar Hallatschek1

  • 1Departments of Physics and Integrative Biology, University of California, Berkeley, California 94720, USA.

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Cellular jamming in confined spaces causes high pressures that slow growth. This mechanical feedback rigidifies cell populations, increasing their stiffness and altering their bulk properties.

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Area of Science:

  • * Biophysics
  • * Cellular mechanics
  • * Soft matter physics

Background:

  • * Cellular populations in confined spaces can transition from fluid-like to solid-like states via jamming.
  • * Jammed budding yeast populations generate significant compressive pressures (>1 MPa).
  • * These pressures impact cellular physiology, potentially slowing or halting cell growth.

Purpose of the Study:

  • * To investigate the impact of mechanical feedback on the properties of jammed cell populations.
  • * To understand how single-cell growth regulation influences population-level mechanics.

Main Methods:

  • * Numerical simulations of model jammed cell populations.
  • * Analysis of how feedback mechanisms affect cell-cell contacts and mechanical properties.

Main Results:

  • * Feedback directs growth towards less coordinated regions within the cell packing.
  • * This leads to an increased number of cell-cell contacts, enhancing rigidity.
  • * Simulated cell packings exhibit significantly increased shear and bulk moduli.
  • * Mechanical properties are sensitive to the strength of the feedback mechanism.

Conclusions:

  • * Mechanical feedback at the single-cell level is a key factor in tuning population-level mechanical properties.
  • * This feedback mechanism can rigidify cell packings and alter their bulk moduli.
  • * Living systems may utilize this feedback to control their collective mechanical behavior.