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Pseudoatrophy of the brain with valproic acid monotherapy
1Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Abstract:
A patient is described who, while on valproic acid monotherapy, developed reversible shrinkage of the brain, documented by computerized tomography with associated cognitive deficit. Although pseudoatrophy has been reported with steroid therapy, this is the first implication of an anticonvulsant drug in the etiology of that condition.