Related Experiment Videos
Intravascular bronchioloalveolar tumor
M Miettinen1, Y Collan, P Halttunen
1Department of Pathology, University of Helsinki, Finland.
Cancer
|November 15, 1987
Summary
This case study follows a patient with intravascular bronchioloalveolar tumor (IVBAT) over 24 years, highlighting its recurrent nature and mesenchymal origin. Despite multiple surgeries, the patient survived longer than previously reported for this rare pulmonary neoplasm.
Area of Science:
- Pulmonary Pathology
- Surgical Oncology
- Medical Histology
Background:
- Intravascular bronchioloalveolar tumor (IVBAT) is a rare pulmonary neoplasm.
- This report details a unique case of IVBAT with extensive recurrence over 24 years.
Observation:
- A 17-year-old female underwent multiple surgeries for recurrent IVBAT.
- Tumor recurred in the lungs, mediastinum, pleura, and retroperitoneal space over 24 years.
- The patient succumbed to pneumonia secondary to respiratory compromise.
Findings:
- Histological analysis confirmed IVBAT in all recurrent tumors.
- Immunohistochemistry revealed vimentin positivity, suggesting a mesenchymal origin.
- Tumor cells lacked definitive endothelial, epithelial, or histiocytic markers.
Implications:
- This case represents the longest survival reported for IVBAT.
- Surgical management was the primary treatment, with no radiotherapy or chemotherapy used.
- The precise cellular origin of IVBAT remains uncertain, classified as a low-grade malignant mesenchymal neoplasm.