Related Experiment Video
Updated: Jan 23, 2026
Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Immunotherapy for renal cell carcinoma
1a Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute , Cleveland , OH , USA.
Abstract:
Introduction: Advanced renal cell cancers (aRCC) has historically been responsive to immune system manipulation. A better understanding of the anti-tumor immune response has fueled the emergence of immunotherapy-based regimens, including combinations with vascular endothelial growth factor (VEGF) inhibitors. Areas covered: In this review, we will describe the historic use of immunotherapies and their integration with newer agents, specifically in clear cell aRCC. Expert opinion: Novel immunotherapeutic agents, as well as combinations with VEGF/TKI therapy, will become the standard of care initial therapy in the management of aRCC. Further studies in the sequencing of drug administration, managing treatment-related adverse events (TRAE), and exploring innovative approaches are warranted.
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