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Breakthrough Moments: Yoshiki Sasai's Discoveries in the Third Dimension
Jessica Mariani1, Flora M Vaccarino2
1Child Study Center, Yale University, New Haven, CT 06520, USA.
Cell Stem Cell
|June 8, 2019
Abstract:
Yoshiki Sasai pioneered the organoid field with his idea of mimicking embryonic development in 3D. We shine a spotlight on his seminal work describing how the innate ability of embryonic stem cells to self-organize into layers and grow in a polarized fashion fosters their appropriate differentiation and response to morphogens.