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Updated: Jan 23, 2026

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
Published on: January 1, 2017
Radicicol enhances the regeneration of skeletal muscle injured by crotoxin via decrease of NF-kB activation
T L Nascimento1, T C Conte1, T S Rissato1
1Department of Anatomy, Biomedical Sciences Institute, University of São Paulo. Av. Lineu Prestes 2415, 05508-000, São Paulo, SP, Brazil.
Abstract:
This study evaluated cellular and molecular effects of radicicol, a heat shock protein (HSP) inducer, on the regeneration of skeletal muscle injured by crotoxin, the main toxin isolated from Crotalus durissus terrificus venom. Regenerating muscles treated with radicicol had decreased NF-kB activation. Differentiating myoblasts treated with radicicol showed reduced number of NF-kB positive nuclei and increased fusion index. The results suggest that radicicol enhances regeneration of muscle by attenuating NF-kB activation and increasing myogenic differentiation.
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