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Updated: Jan 23, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
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Published on: June 23, 2014

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News and meta-analysis regarding anti-Beta 2 glycoprotein I antibodies and their determination

Eléonore Bettacchioli1, Salma Nafai1, Yves Renaudineau2

  • 1Laboratory of Immunology and Immunotherapy, CHU, Brest, France.

Clinical Immunology (Orlando, Fla.)
|June 8, 2019
PubMed

Recent advances allow us to propose antibodies targeting beta-2-glycoprotein I (β2-GPI) as the most specific antibodies associated with anti-phospholipid syndrome (APS). Therefore, there is now a crucial need for powerful biological assays to adequately monitor them. It is well established that these antibodies recognize mainly cryptic epitopes, which requires a great deal of consideration in the choice of laboratory tests to identify these antibodies. To this end, an update on the pathophysiological role of β2-GPI and a meta-analysis were conducted providing an overview of the current progress towards anti-β2-GPI detection.

Keywords:
Anti-phospholipid syndromeChemiluminescenceELISAThrombosisβ(2)-glycoprotein I antibodies

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