Related Experiment Video
Updated: Jan 23, 2026

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
The safety evaluation of long-acting ocular delivery systems
Evan A Thackaberry1, Florence Lorget2, Cindy Farman3
1Ra Pharmaceuticals, 87 Cambridge Park Dr, Cambridge, MA 02140, USA.
Abstract:
The safety evaluation of ocular long-acting delivery (LAD) technologies is a nascent field. Here, we detail the challenges in assessing the safety of novel LAD technologies, and well as the most common types of toxicity encountered during early toxicity testing. A detailed understanding of the route of administration, pharmacology, and functionality and/or pharmacokinetics (PK) of the LAD, along with all of its component parts, including the active pharmaceutical ingredient and excipients, is crucial for the successful development of next-generation long-acting ocular therapeutics.
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