Revisiting mTOR inhibitors as anticancer agents.

Area of Science:

• Biochemistry
• Molecular Biology
• Oncology

Background:

• The mammalian target of rapamycin (mTOR) is a key kinase regulating cellular functions.
• Dysregulation of mTOR signaling is implicated in various cancers.
• Targeting mTOR offers a promising strategy for cancer therapy.

Purpose of the Study:

• To review the function and regulation of the mTOR signaling pathway.
• To summarize the diverse roles of mTOR in cancer development.
• To present an overview of mTOR inhibitors as anticancer agents.

Main Methods:

• Literature review of mTOR signaling pathways.
• Analysis of mTOR's role in different cancer types.
• Compilation of existing and emerging mTOR inhibitors.

Main Results:

• mTOR pathway controls cell growth, metabolism, and survival.
• mTOR signaling is frequently altered in human cancers.
• Various mTOR inhibitors show efficacy in preclinical and clinical studies.

Conclusions:

• Understanding mTOR signaling is crucial for cancer treatment.
• mTOR inhibitors represent a valuable class of anticancer drugs.
• Further research can optimize mTOR-targeted therapies for improved patient outcomes.