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Revisiting mTOR inhibitors as anticancer agents

Qiu-Xu Teng1, Yunali V Ashar1, Pranav Gupta1

  • 1Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.

Drug Discovery Today
|June 8, 2019
PubMed

Insights

The mammalian target of rapamycin (mTOR) pathway regulates cell processes and impacts cancer. Investigating mTOR signaling and inhibitors may reveal new anticancer therapeutic opportunities.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The mammalian target of rapamycin (mTOR) is a key kinase regulating cellular functions.
  • Dysregulation of mTOR signaling is implicated in various cancers.
  • Targeting mTOR offers a promising strategy for cancer therapy.

Purpose of the Study:

  • To review the function and regulation of the mTOR signaling pathway.
  • To summarize the diverse roles of mTOR in cancer development.
  • To present an overview of mTOR inhibitors as anticancer agents.

Main Methods:

  • Literature review of mTOR signaling pathways.
  • Analysis of mTOR's role in different cancer types.
  • Compilation of existing and emerging mTOR inhibitors.

Main Results:

  • mTOR pathway controls cell growth, metabolism, and survival.
  • mTOR signaling is frequently altered in human cancers.
  • Various mTOR inhibitors show efficacy in preclinical and clinical studies.

Conclusions:

  • Understanding mTOR signaling is crucial for cancer treatment.
  • mTOR inhibitors represent a valuable class of anticancer drugs.
  • Further research can optimize mTOR-targeted therapies for improved patient outcomes.

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