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Two Pathways Regulate Differential Expression of nAChRs Between the Orbicularis Oris and Gastrocnemius

Shuang Wu1, Yong Huang1, Yian Xing1

  • 1Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The Journal of Surgical Research
|June 8, 2019
PubMed
Summary

The neuregulin1/ErbB pathway regulates nicotinic acetylcholine receptor expression in facial muscles. Facial nerve injury upregulates MuSK and rapsyn, contributing to altered receptor expression and muscle relaxant sensitivity.

Keywords:
Facial nerve injuryMatrix metalloproteinase 3Neuromuscular junctionNicotinic acetylcholine receptorSynaptic plasticity

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