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Updated: Jan 23, 2026

Author Spotlight: Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks
Published on: June 9, 2023
Multifunctional iron-based Metal-Organic framework as biodegradable nanozyme for microwave enhancing dynamic therapy
Xiaoyan Ma1, Xiangling Ren2, Xudong Guo3
1Laboratory of Controllable Preparation and Application of Nanomaterials, Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Beijing, 100190, China; State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock,Inner Mongolia University, 24 Zhaojun Road, Hohhot, 010070, China.
This study introduces biodegradable nanozymes (MIL-101(Fe) NPs) for cancer therapy. These nanozymes combine microwave-enhanced dynamic therapy (MEDT) and microwave thermal therapy (MTT), achieving a 96.65% tumor kill rate.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Nanozymes offer enzyme-mimicking catalytic properties for tumor diagnosis and therapy.
- Fe-metal organic framework nanoparticles (MIL-101(Fe) NPs) are explored as biodegradable nanozymes.
Purpose of the Study:
- To develop MIL-101(Fe) NPs for reactive oxygen species (ROS) generation and cancer cell death via microwave enhancing dynamic therapy (MEDT).
- To integrate dual-mode imaging (fluorescent imaging and MRI) and combine MEDT with microwave thermal therapy (MTT) for enhanced anti-tumor efficacy.
Main Methods:
- MIL-101(Fe) NPs were synthesized and functionalized with fluorescent gold nanoclusters (BSA-Au NCs) to form MIL-101(Fe)@BSA-AuNCs NPs.
- Ionic liquid (IL) was loaded for microwave sensitivity, enabling combined MTT and MEDT.
- In vivo experiments were conducted to evaluate anti-tumor efficacy and imaging capabilities.
Main Results:
- MIL-101(Fe)@BSA-AuNCs NPs demonstrated effective ROS generation under microwave irradiation.
- Dual-mode imaging accurately located tumors and monitored nanoparticle distribution, with peak signals at 1h (liver) and 5h (tumor).
- The combined MTT and MEDT strategy achieved a significant tumor kill rate of 96.65%.
Conclusions:
- Biodegradable MIL-101(Fe)@BSA-AuNCs NPs offer a promising platform for combined microwave therapies (MTT and MEDT).
- The developed nanozymes provide dual-mode imaging and efficient tumor eradication, highlighting their potential in advanced cancer treatment.
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