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Updated: Jan 23, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

10.2K

Phase 2 study of vascular endothelial growth factor trap for the treatment of metastatic thyroid cancer

Eric J Sherman1,2, Lara A Dunn1,2, Heiko Schöder3

  • 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Cancer
|June 8, 2019
PubMed
Abstract

Insights

Vascular Endothelial Growth Factor (VEGF) Trap did not show significant responses in patients with advanced thyroid cancer. This study suggests VEGF Trap is not a promising treatment for this condition.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trials

Background:

  • Multitargeted tyrosine kinase inhibitors (TKIs) show activity in radioactive iodine-refractory thyroid cancer, partly by inhibiting angiogenesis.
  • Vascular Endothelial Growth Factor (VEGF) Trap (VT) targets VEGF, a key factor in tumor vascularization.

Purpose of the Study:

  • To evaluate the efficacy of single-agent VEGF Trap in patients with progressive, radioactive iodine-refractory thyroid cancer.
  • To assess objective response rate and 6-month progression-free survival as primary endpoints.

Main Methods:

  • Phase 2, single-institution, Simon 2-stage design study.
  • 40 patients with progressive, RAI-refractory, recurrent/metastatic nonmedullary thyroid cancer received VEGF Trap (4 mg/kg IV every 14 days).
  • Disease measured by RECIST criteria.

Main Results:

  • No complete or partial responses were observed in 40 patients.
  • 34 patients achieved stable disease; 6 experienced disease progression.
  • Median treatment duration was 4.1 months; 16 patients had stable disease for over 6 months.

Conclusions:

  • Single-agent VEGF Trap demonstrated no objective responses in this patient cohort.
  • VEGF Trap does not appear to be a promising therapeutic option for advanced thyroid cancer.
Keywords:
phase 2radioactive iodine (RAI)-refractorythyroid cancervascular endothelial growth factor receptor (VEGF) Trap

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