Related Experiment Video
Updated: Jan 23, 2026
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
1.1K
mTOR and Aging: An Old Fashioned Dress
Giovanni Stallone1, Barbara Infante2, Concetta Prisciandaro3
1Department of Medical and Surgical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, Italy. giovanni.stallone@unifg.it.
International Journal of Molecular Sciences
|June 9, 2019
Summary
Aging involves cellular function decline, a key risk factor for diseases. The mTOR signaling pathway is central to aging and dietary restriction
Area of Science:
- Gerontology and molecular biology
- Cellular and molecular mechanisms of aging
Background:
- Aging is a complex process involving cellular dysfunction and molecular pathway alterations.
- This deterioration increases susceptibility to injury and is a primary risk factor for major human pathologies.
- Hallmarks of aging include genomic instability, telomere erosion, epigenetic alterations, and mitochondrial dysfunction.
Purpose of the Study:
- To discuss the role of the mammalian target of rapamycin (mTOR) signaling network in aging.
- To explore mTOR's involvement in age-related diseases, specifically cardiovascular disease, immune response, and cancer.
Main Methods:
- Review of existing literature on aging, mTOR signaling, and age-related diseases.
- Analysis of studies in model organisms (flies, worms, yeast, mice) investigating mTOR's role in aging.
- Focus on the impact of mTOR on cardiovascular, immune, and cancer systems in the context of aging.
Main Results:
- The mTOR signaling network is evolutionarily conserved and plays a pivotal role in modulating aging.
- mTOR is a key mediator of the lifespan-extending and disease-slowing effects of dietary restriction.
- Dysregulation of mTOR signaling is implicated in the development of age-related cardiovascular disease, immune decline, and cancer.
Conclusions:
- The mTOR signaling network is a critical regulator of aging and age-related diseases.
- Targeting mTOR pathways may offer therapeutic strategies to combat age-related pathologies.
- Understanding mTOR's role is crucial for developing interventions to promote healthy aging.
Related Concept Videos
03:03mTOR Signaling and Cancer Progression
4.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.7K
01:22PI3K/mTOR/AKT Signaling Pathway
5.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.4K
01:26Aging
636
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
636
01:19The Effect of Aging on Tissues
3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
01:09Changes in the Appendicular Skeleton with Age
3.4K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.4K
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
192
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
192