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Interactive effects of AURKA polymorphisms with smoking on the susceptibility of oral cancer
Chao Huang1, Lili Wang2, Hongguang Song3
1a Department of Stomatology, The First Affiliated Hospital of Jinzhou Medical University , Jinzhou , China.
Abstract:
Objective: The objective of this study was aimed to investigate the interactions between Aurora kinase A (AURKA) gene polymorphisms (T91A and G169A) and smoking and their effects on the susceptibility of oral cancer. Methods: One hundred five healthy controls were frequency-matched with 91 oral cancer patients by age, sex and nationality. Detection of AURKA T91A and G169A polymorphisms was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Differences in genotypes and alleles between case and control groups were compared using χ2 test. Relative risk of oral cancer was presented as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: AA genotypes respectively of AURKA T91A and G169A polymorphisms had higher frequencies in case group than in control group (p = .023; p = .038). However, only 91AA genotype was significantly associated with the occurrence of oral cancer risk (OR = 3.113, 95% CI = 1.176-8.236). A alleles of the two polymorphisms respectively increased the risk of oral cancer (OR = 1.700, 95% CI = 1.113-2.596; OR = 1.978, 95% CI = 1.132-3.454). Interactions between smoking and AURKA polymorphisms significantly associated with the onset of oral cancer (p < .05). Conclusions: AURKA polymorphisms are susceptible factors for oral cancer. Interactions between AURKA polymorphisms and smoking increase the risk of oral cancer.
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