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Updated: Jan 23, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities

Philamer C Calses1, James J Crawford2, Jennie R Lill3

  • 1Department of Discovery Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Trends in Cancer
|June 9, 2019
PubMed

Insights

The Hippo pathway regulates development and its dysregulation drives cancer. This review covers Hippo pathway's role in cancer genetics, therapy resistance, and immunogenicity, summarizing therapeutic targeting efforts.

Area of Science:

  • Oncology
  • Molecular Biology
  • Developmental Biology

Background:

  • The Hippo pathway is crucial for organ size control and development.
  • Its dysregulation is implicated in numerous human cancers.
  • Targeting the Hippo pathway is a key strategy for cancer intervention.

Purpose of the Study:

  • To review recent advances in understanding the Hippo pathway in cancer.
  • To discuss genetic aberrations affecting Hippo pathway components in tumorigenesis.
  • To explore the Hippo pathway's role in cancer therapy resistance and immunogenicity.

Main Methods:

  • Literature review of recent research on the Hippo pathway and cancer.
  • Analysis of genetic alterations (amplification, deletion, fusion) in Hippo pathway genes.
  • Examination of studies on Hippo pathway's influence on therapeutic response and anti-tumor immunity.

Main Results:

  • Genetic aberrations in core Hippo pathway factors are mechanisms of cancer development.
  • The Hippo pathway influences resistance to cancer therapies.
  • Hippo pathway activity impacts tumor immunogenicity.

Conclusions:

  • The Hippo pathway is a significant factor in cancer biology, affecting development and progression.
  • Understanding its genetic underpinnings and roles in therapy resistance and immunity is vital.
  • Targeting the Hippo pathway holds promise for novel cancer treatments.
Keywords:
Hippo pathwayTAZTEADYAPcancerdrug development

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