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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
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Appendicitis-II: Diagnostic Studies and Management01:29

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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Prediction Intervals01:03

Prediction Intervals

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The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
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Confidence Intervals01:21

Confidence Intervals

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An unbiased point estimate is often insufficient to predict a population estimate, such as population mean or population proportion. In this scenario, a confidence interval is used. A confidence interval is an estimate similar to a  sample proportion. However, unlike the point estimate which is a single value, the confidence interval  contains a range of values. These values have lower and upper limits, known as confidence limits, and can be designated as L1 and L2, respectively.
A...
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Uncertainty: Confidence Intervals00:54

Uncertainty: Confidence Intervals

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The confidence interval is the range of values around the mean that contains the true mean. It is expressed as a probability percentage. The interpretation of a 95% confidence interval, for instance, is that the statistician is 95% confident that the true mean falls within the interval. The upper and lower limits of this range are known as confidence limits. The confidence limits for the true mean are estimated from the sample's mean, the standard deviation, and the statistical factor...
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Interpretation of Confidence Intervals01:19

Interpretation of Confidence Intervals

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A confidence interval is a better estimate of the population than a point estimate, as it uses a range of values from a sample instead of a single value.
Confidence intervals have confidence coefficients that are crucial for their interpretation. The most common confidence coefficients are 0.90, 0.95, and 0.99, which can be written as percentages–90%, 95%, and 99%, respectively.
Suppose a person calculates a confidence interval with a confidence coefficient of 0.95. In that case, they can...
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Related Experiment Video

Updated: Jan 23, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Predictors for interval appendectomy in non-operatively treated complicated appendicitis.

J de Jonge1, M D M Bolmers2, G D Musters3

  • 1Department of Surgery, Tergooi Hospital Hilversum, P.O. Box 10016, 1201DA, Hilversum, The Netherlands. jdejonge@tergooi.nl.

International Journal of Colorectal Disease
|June 9, 2019
PubMed
Summary
This summary is machine-generated.

One in three patients with complicated appendicitis treated non-operatively required an interval appendectomy. This group also showed a higher incidence of appendicular neoplasms, suggesting the need for further imaging.

Keywords:
AppendicitisAppendicular neoplasmInflammatory massInterval appendectomyNon-operative treatment

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Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Radiology

Background:

  • Complicated appendicitis is often treated non-operatively.
  • Interval appendectomy is a potential subsequent treatment.
  • Predictive factors and outcomes require further investigation.

Purpose of the Study:

  • To determine the incidence rate of interval appendectomy after non-operative treatment for complicated appendicitis.
  • To identify predictive factors for undergoing interval appendectomy.
  • To assess the incidence of appendicular neoplasms in patients undergoing interval appendectomy.

Main Methods:

  • Retrospective cohort study (2008-2017) of adult patients with acute appendicitis.
  • Inclusion of patients with complicated appendicitis initially treated non-operatively.
  • Analysis of outcomes including abscess rates, interval appendectomy incidence, and histological findings.

Main Results:

  • 9% of acute appendicitis patients (170/1839) were initially treated non-operatively.
  • 37.6% (64/170) of these patients underwent interval appendectomy, most commonly for recurrent appendicitis.
  • Increasing age was associated with a lower risk of interval appendectomy (OR 0.7).
  • Appendicular neoplasms were found in 11% of interval appendectomy patients versus 1.5% of those with acute surgery.

Conclusions:

  • Approximately one-third of non-operatively treated complicated appendicitis patients require interval appendectomy.
  • A significant incidence of appendicular neoplasms was observed in the interval appendectomy group.
  • Routine radiological imaging is recommended for patients with non-operatively treated complicated appendicitis.