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A 2019 update on TSH-secreting pituitary adenomas
P Beck-Peccoz1, C Giavoli2, A Lania3,4
1University of Milan, Milan, Italy.
Journal of Endocrinological Investigation
|June 9, 2019
Summary
Thyrotropin-secreting pituitary adenomas (TSH-omas) are rare causes of hyperthyroidism. Differentiating them from thyroid hormone resistance is crucial for proper patient management and preventing complications.
Area of Science:
- Endocrinology
- Oncology
Background:
- Thyrotropin-secreting pituitary adenomas (TSH-omas) cause hyperthyroidism with elevated thyroid hormones and measurable TSH.
- TSH-omas are rare, <1% of pituitary adenomas, leading to limited data.
Purpose of the Study:
- To review recent advances in the pathophysiology, diagnosis, and treatment of TSH-omas.
- To highlight the importance of distinguishing TSH-omas from thyroid hormone resistance (RTH).
Main Methods:
- Literature review of recent research on TSH-omas.
Main Results:
- New research provides insights into TSH-oma etiopathogenesis.
- Biochemical similarities with pituitary RTH can complicate diagnosis.
Conclusions:
- Accurate diagnosis and timely treatment of TSH-omas are essential to avoid neurological and endocrinological complications.
- Early intervention improves cure rates for TSH-secreting pituitary adenomas.
Keywords:
Central hyperthyroidismFree T3Free T4Resistance to thyroid hormonesSomatostatin analogsTSH-omaThyrotropinThyrotropin-secreting pituitary adenomaTranssphenoidal surgeryMore Related Videos
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