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Related Experiment Video

Updated: Jan 23, 2026

Extraction and Analysis of Cortisol from Human and Monkey Hair
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Human-Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges.

Alejandro De Los Angeles1, Insoo Hyun2, Stephen R Latham3

  • 1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Methods in Molecular Biology (Clifton, N.J.)
|June 9, 2019
PubMed
Summary

Creating human-primate chimeras using human pluripotent stem cells could improve disease modeling but raises significant ethical concerns regarding invasive research on non-ape primates.

Keywords:
ChimerasDisease modelingHuman-monkey chimerasInterspecies chimerasNaïve pluripotencyNaïve pluripotent stem cellsNonhuman primatesPluripotencyPrimed pluripotent stem cellsReprogrammingStem cells

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Area of Science:

  • Biomedical Research
  • Stem Cell Biology
  • Neuroscience

Background:

  • Developing accurate animal models for human diseases remains a significant challenge in biomedical research.
  • Advances in pluripotent stem cell (PS cell) technology and chimera research offer new possibilities for creating more relevant disease models.

Purpose of the Study:

  • To explore the potential of human-primate chimeras, specifically using human stem cells in non-ape primate hosts, as improved models for neurological and psychiatric diseases.
  • To address the urgent ethical and scientific considerations surrounding the creation and use of such human-animal chimeras.

Main Methods:

  • The study discusses the theoretical application of blastocyst complementation experiments involving human stem cells and primate embryos.
  • It reviews recent advances in PS cell research and interspecies chimera generation techniques.

Main Results:

  • Human-primate chimeras could potentially overcome limitations of current non-human primate models for studying complex human neurological and psychiatric conditions.
  • The creation of these chimeras necessitates careful consideration of ethical issues, including invasive research practices and the moral status of chimeras.

Conclusions:

  • The development of human-primate chimeras presents a promising avenue for advancing disease modeling but requires a thorough ethical and regulatory framework.
  • Navigating the scientific potential against ethical concerns is crucial, especially given varying global regulations on human stem cell research in animal models.