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Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
Published on: October 11, 2012
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Ferroptosis - An iron- and disorder-dependent programmed cell death
Mak B Djulbegovic1, Vladimir N Uversky2
1Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
International Journal of Biological Macromolecules
|June 9, 2019
Summary
Intrinsically disordered proteins (IDPs) and regions (IDPRs) are prevalent in ferroptosis, a form of programmed cell death. This intrinsic disorder in ferroptosis-related proteins impacts protein interactions and molecular functions.
Area of Science:
- Cell Biology
- Biochemistry
- Genetics
Background:
- Programmed cell death (PCD) is vital for organism development and pathology.
- Ferroptosis, a novel iron- and reactive oxygen species-dependent PCD, is linked to protein-protein interaction (PPI) networks.
- Intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) drive interactability in PCD-related PPIs, enhancing regulatory control.
Purpose of the Study:
- To investigate the association between intrinsic disorder and ferroptosis-related proteins.
- To understand the prevalence and functional implications of IDPs/IDPRs in ferroptosis.
- To explore the evolutionary conservation of intrinsic disorder in ferroptosis.
Main Methods:
- Analysis of 31 human ferroptosis-related proteins using bioinformatics and computational techniques.
- Utilized a disorder meta-predictor (PONDR® FIT) to assess evolutionary conservation of intrinsic disorder.
- Examined protein-protein interaction (PPI) networks and molecular interactions.
Main Results:
- Demonstrated the prevalence of intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) in ferroptosis.
- Identified significant functional implications of intrinsic disorder in ferroptosis-related PPIs.
- Showcased the evolutionary conservation of intrinsic disorder within these proteins.
Conclusions:
- Intrinsic disorder is a key feature of ferroptosis.
- IDPs and IDPRs play crucial roles in the molecular mechanisms and regulation of ferroptosis.
- Understanding intrinsic disorder in ferroptosis is essential for comprehending its role in health and disease.
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