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Related Experiment Video

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Dopamine-mediated immunomodulation affects choroid plexus function.

Giulia Castellani1, Gabriella Contarini1, Maddalena Mereu1

  • 1Genetics of Cognition Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genova, Italy; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, L.go Meneghetti, 2, 35131 Padova, Italy.

Brain, Behavior, and Immunity
|June 9, 2019
PubMed
Summary
This summary is machine-generated.

Dopamine transporter (DAT) hypofunction alters immune tolerance and brain immune cell activity. Modulating the choroid plexus (CP) gateway may offer new therapeutic avenues for psychiatric disorders like ADHD.

Keywords:
ADHDAmphetamineDATMacrophagesMicrogliaPeripheral and CNS immune crosstalk

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Area of Science:

  • Neuroimmunology
  • Psychiatric Pharmacology

Background:

  • Immune system alterations are linked to dopamine-related disorders.
  • The interplay between dopaminergic dysfunction and immunity remains unclear.

Purpose of the Study:

  • To investigate how dopamine transporter (DAT) hypofunction and amphetamine affect peripheral and central immunity.
  • To explore the impact on brain immune cell activity and the choroid plexus (CP) gateway.

Main Methods:

  • Peripheral and cerebral immunophenotyping in mice with genetic DAT hypofunction and amphetamine administration.
  • Analysis of Treg cells, adrenomedullin, microglia, and monocyte-derived macrophages (mo-MΦ).

Main Results:

  • DAT hypofunction increased Tregs and adrenomedullin, reduced microglia activation and mo-MΦ infiltration.
  • Both DAT hypofunction and amphetamine weakened CP activation, but amphetamine reactivated CP in DAT hypofunction mice.
  • CP reactivation correlated with ADHD-relevant behaviors.

Conclusions:

  • Dopaminergic dysfunction impacts immune tolerance and brain immune surveillance.
  • Choroid plexus (CP) gateway modulation is a potential therapeutic strategy for neurodevelopmental and psychiatric disorders.