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General-purpose passive wireless point-of-care platform based on smartphone.

Pablo Escobedo1, Miguel M Erenas2, Antonio Martínez-Olmos1

  • 1ECsens, CITIC-UGR, Department of Electronics and Computer Technology, University of Granada, Campus Aynadamar, 18071, Granada, Spain; Unit of Excellence in Chemistry applied to Biomedicine and the Environment of the University of Granada, Granada, Spain.

Biosensors & Bioelectronics
|June 9, 2019
PubMed
Summary

A new, low-cost analytical platform using smartphones enables point-of-care testing. This versatile system supports electrochemical and electrochemiluminescence techniques for accurate sample analysis.

Keywords:
Electrochemical techniquesElectrochemiluminescenceEnergy harvestingNear-field communicationPassive point-of-care platformSmartphone

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Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Electrical Engineering

Background:

  • Point-of-care testing (POCT) requires accessible, low-cost analytical devices.
  • Existing POCT platforms often lack versatility and smartphone integration.
  • Smartphone-based analytical systems offer potential for remote diagnostics and data sharing.

Purpose of the Study:

  • To design, test, and validate a compact, low-cost analytical platform for POCT.
  • To integrate electrochemical and electrochemiluminescence techniques with smartphone control.
  • To demonstrate the platform's utility for determining clinically relevant analytes.

Main Methods:

  • Development of a passive measurement system powered by a smartphone.
  • Utilization of screen-printed electrodes and off-the-shelf electronic components.
  • In-depth study of power, electrical, and optical signal processing.
  • Validation using amperometric, potentiometric, cyclic voltammetry, and electrochemiluminescent techniques.

Main Results:

  • The platform achieves energy harvesting up to 22.5 µW and voltage control of ±1.15 V.
  • Accurate potential and current measurements were demonstrated with high resolution.
  • Analytical techniques showed excellent agreement with a reference instrument.
  • Successful determination of glucose, H2O2, and pH with clinically relevant ranges and low limits of detection.

Conclusions:

  • The developed analytical platform is versatile, compact, and cost-effective (
  • Smartphone integration enables easy configuration, data processing, and wireless sharing.
  • The platform is suitable for various analytical applications in point-of-care settings.