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Consistency checks to improve measurement with the Montgomery-Asberg Depression Rating Scale (MADRS)
Jonathan Rabinowitz1, Nina R Schooler2, Brianne Brown3
1Bar Ilan University, Ramat Gan, Israel.
Abstract:
International Society for CNS Clinical Trials and Methodology convened an expert Working Group that assembled consistency/inconsistency flags for the Montgomery-Asberg Depression Rating Scale (MADRS). Twenty-two flags were identified. Seven flags are believed to be strong flags that suggest that a thorough review of rating is warranted. The flags were applied to assessments derived from the NEWMEDS data repository. Almost 65% of ratings had at least one inconsistency flag raised and 22% had two or more. Application of flags to clinical ratings may improve reliability of ratings and validity of trials.
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