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Probiotics may not prevent the deterioration of necrotizing enterocolitis from stage I to II/III

Zheng-Li Wang1,2,3, Li Liu1,2,3, Xiao-Yu Hu1,2,3

  • 1Department of Neonatal Diagnosis and Treatment Center, Children's Hospital of Chongqing Medical University, No 136, Zhong shan 2 Road, Yuzhong district, Chongqing, 400014, People's Republic of China.

BMC Pediatrics
|June 10, 2019
PubMed

Insights

Probiotics did not significantly prevent necrotizing enterocolitis (NEC) from worsening in infants. Sepsis was identified as a risk factor for NEC deterioration, warranting further investigation.

Area of Science:

  • Neonatal Medicine
  • Gastroenterology
  • Microbiology

Background:

  • Probiotic therapy is known to reduce the incidence of necrotizing enterocolitis (NEC).
  • The efficacy of probiotics in preventing NEC severity progression after diagnosis remains unclear.
  • This study investigated probiotics' role in preventing NEC stage I to II/III deterioration.

Purpose of the Study:

  • To evaluate the effect of probiotic use on preventing the deterioration of necrotizing enterocolitis (NEC) from stage I to II/III.
  • To identify risk factors associated with NEC deterioration.

Main Methods:

  • Retrospective matched cohort study comparing probiotic and no-probiotic groups.
  • Matched 81 pairs of infants based on gestational age and birth weight.
  • Case-control analysis to identify independent risk factors for NEC deterioration.

Main Results:

  • No significant difference in NEC deterioration rates between probiotic and no-probiotic groups, both before (23.1% vs 26.0%) and after matching (21.0% vs 27.2%).
  • Sepsis following NEC was identified as an independent risk factor for deterioration from stage I to II/III (OR 2.378).

Conclusions:

  • Probiotics may not prevent NEC deterioration from stage I to II/III in infants.
  • Sepsis is a significant risk factor for NEC progression.
  • Findings should be interpreted with caution, suggesting further research is needed.
Abstract

Keywords:
Intestinal diseasesMatched case-control studyMicrobiota

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