Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleolus02:55

The Nucleolus

10.3K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.3K
The Nucleolus02:55

The Nucleolus

5.8K
5.8K
Nuclear Stability03:18

Nuclear Stability

23.0K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.0K
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

23.1K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
23.1K
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

8.7K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
8.7K
The Central Dogma01:25

The Central Dogma

139.1K
Overview
139.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treacle-dependent TOPBP1 condensation regulates the nucleolar DNA damage response.

Nucleic acids research·2026
Same author

Olivetol induces a non-genotoxic nucleolar DNA damage response via membrane-dependent stress signaling.

Nucleus (Austin, Tex.)·2026
Same author

A Toolbox for Quantifying Nuclear and Nucleolar Protein Accumulation Using NLS and NoLS Fusion Reporters.

Traffic (Copenhagen, Denmark)·2026
Same author

The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine.

Trends in biochemical sciences·2026
Same author

Extrusion fountains are hallmarks of chromosome organization emerging upon zygotic genome activation.

Nature communications·2026
Same author

Evaluating imputation methods for accurate estimation of cell population fractions in single-cell RNA sequencing.

NAR genomics and bioinformatics·2026

Related Experiment Video

Updated: Jan 23, 2026

Production of Synthetic Nuclear Melt Glass
04:36

Production of Synthetic Nuclear Melt Glass

Published on: January 4, 2016

9.9K

Nucleolus: A Central Hub for Nuclear Functions.

Olga V Iarovaia1, Elizaveta P Minina2, Eugene V Sheval3

  • 1Institute of Gene Biology of the Russian Academy of Sciences, 119334 Moscow, Russia; LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, 94805 Villejuif, France.

Trends in Cell Biology
|June 10, 2019
PubMed
Summary

The nucleolus, a key nuclear body, orchestrates vital cellular functions beyond ribosome production. Its role as a hub for protein and nucleic acid shuttling impacts genome organization, DNA repair, and stress responses.

Keywords:
3D genome organizationDNA repair and recombinationnuclear compartmentalizationnucleolustranscription

More Related Videos

Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins
10:03

Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins

Published on: August 10, 2014

12.5K
Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
13:15

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

Published on: February 25, 2016

12.4K

Related Experiment Videos

Last Updated: Jan 23, 2026

Production of Synthetic Nuclear Melt Glass
04:36

Production of Synthetic Nuclear Melt Glass

Published on: January 4, 2016

9.9K
Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins
10:03

Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins

Published on: August 10, 2014

12.5K
Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1
13:15

Experimental Approaches to Study Mitochondrial Localization and Function of a Nuclear Cell Cycle Kinase, Cdk1

Published on: February 25, 2016

12.4K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The nucleolus is a prominent nuclear substructure, traditionally known for ribosome biogenesis.
  • Its broader roles in nuclear organization and function are increasingly recognized.
  • Understanding nucleolar function is crucial for comprehending cellular health and disease.

Purpose of the Study:

  • To explore the multifaceted roles of the nucleolus in nuclear functions.
  • To discuss the mechanisms by which nucleolar components shuttle between the nucleolus and nucleoplasm.
  • To highlight the impact of nucleolar shuttling on essential cellular processes.

Main Methods:

  • Literature review and synthesis of existing research on nucleolar function.
  • Analysis of studies investigating nucleolar protein and nucleic acid dynamics.
  • Discussion of experimental evidence supporting nucleolar involvement in various cellular pathways.

Main Results:

  • The nucleolus acts as an organizing hub for diverse nuclear functions.
  • Shuttling of proteins and nucleic acids is a key mechanism for nucleolar influence.
  • Nucleolar shuttling impacts genome 3D organization, DNA repair, stress response, and transcription.

Conclusions:

  • The nucleolus plays a critical, yet underappreciated, role in regulating fundamental cellular processes.
  • Further research into nucleolar dynamics will illuminate its significance in maintaining nuclear homeostasis.
  • Targeting nucleolar functions may offer novel therapeutic strategies for various diseases.