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Updated: Jan 23, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

590

Associations between local haemodynamics and carotid intraplaque haemorrhage with different stenosis severities: A

Yuanyuan Dai1, Yi Qian1, Mingzi Zhang1

  • 1Department of Biomedical Sciences, Faculty of Medicine and Health Science, Macquarie University, NSW 2109, Sydney, Australia.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|June 10, 2019
PubMed

Insights

Maximum wall shear stress (mWSS) is linked to intraplaque haemorrhage (IPH) in carotid atherosclerosis, especially with less severe stenosis. This finding suggests mWSS could aid in diagnosing carotid atherosclerosis risk.

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Medical Imaging

Background:

  • The interplay between carotid blood flow dynamics and intraplaque haemorrhage (IPH) in carotid atherosclerosis remains unclear.
  • Intraplaque haemorrhage is a critical factor in plaque vulnerability and stroke risk.

Purpose of the Study:

  • To investigate the relationship between local hemodynamics, specifically maximum wall shear stress (mWSS), and carotid plaques with IPH.
  • To assess the association between hemodynamic parameters and IPH in patients with varying degrees of carotid artery stenosis.

Main Methods:

  • Fifty-nine patients with carotid atherosclerosis underwent magnetic resonance imaging (MRI) for plaque characterization.
  • Computational fluid dynamics (CFD) simulations were used to calculate mWSS.
  • Patients were categorized into IPH and non-IPH groups, with subgroups for mild, moderate, and severe stenosis.

Main Results:

  • mWSS was significantly higher in the IPH group compared to the non-IPH group for mild (P=0.001) and moderate (P=0.002) stenosis.
  • No significant difference in mWSS was observed between groups for severe stenosis (P=0.42).
  • A strong positive correlation (r=0.763, P<0.001) was found between mWSS and IPH volume in stenosis <70%.

Conclusions:

  • mWSS is significantly associated with IPH in carotid arteries with stenosis less than 70%.
  • mWSS emerges as a potential quantitative biomarker for assessing the risk of carotid atherosclerosis progression and vulnerability.

Keywords:
Carotid atherosclerosisComputational fluid dynamicsIntraplaque haemorrhageMagnetic resonance imagingWall shear stress

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