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Emerging roles for long noncoding RNAs in learning, memory and associated disorders.

Eddie Grinman1, Isabel Espadas1, Sathyanarayanan V Puthanveettil1

  • 1Department of Neuroscience, Scripps Research, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA.

Neurobiology of Learning and Memory
|June 10, 2019
PubMed
Summary

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in learning and memory. This review explores their evolution, function in the central nervous system, and links to memory disorders.

Keywords:
Brain disordersGene expressionHippocampusLTPLearningLong non-coding RNAsMemorySynaptic plasticity

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Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • Protein-coding genes are well-studied in learning and memory.
  • The non-coding genome, particularly long noncoding RNAs (lncRNAs), is a newer area of investigation.
  • lncRNAs are implicated in neurobiological processes and memory impairment disorders.

Purpose of the Study:

  • To review the evolution of lncRNAs in the central nervous system (CNS).
  • To discuss the current understanding of lncRNA involvement in learning and memory.
  • To describe emerging tools for lncRNA research.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of functional profiling and high-throughput sequencing data.
  • Discussion of controversial aspects of lncRNA functionality and evolution.

Main Results:

  • Multiple lncRNAs are functionally linked to learning and memory processes.
  • lncRNAs act as critical regulators of gene expression in the CNS.
  • lncRNAs are associated with memory impairment disorders.

Conclusions:

  • lncRNAs play significant roles in the CNS and learning.
  • Further research is needed to understand lncRNA evolution and function.
  • Emerging tools will advance the study of lncRNAs in neuroscience.