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Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
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Long non-coding RNA DILC suppresses bladder cancer cells progression.
Qian-Yun Ma1, Shu-Ying Li2, Xi-Zhou Li3
1Department of Urology surgery, First Affiliated Hospital of Second Military Medical University, Shanghai 200433, China.
Gene
|June 10, 2019
Summary
Long non-coding RNA DILC (lnc-DILC) acts as a tumor suppressor in bladder cancer (BC). Overexpression of lnc-DILC inhibits BC cell proliferation and metastasis by inactivating the STAT3 pathway.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) play crucial roles in various cancers, including bladder cancer (BC).
- Previous research identified lnc-DILC as a tumor suppressor in liver and colorectal cancers.
- The specific function of lnc-DILC in BC progression was previously unknown.
Purpose of the Study:
- To investigate the role of lnc-DILC in bladder cancer.
- To determine the underlying molecular mechanism of lnc-DILC's function in BC.
Main Methods:
- Analysis of lnc-DILC expression in human bladder cancer tissues.
- Overexpression of lnc-DILC in BC cells to assess effects on proliferation, metastasis, and cancer stem cells (CSCs).
- Utilizing a STAT3 inhibitor (S3I-201) to confirm the involvement of the STAT3 pathway.
Main Results:
- lnc-DILC was found to be downregulated in human bladder cancer tissues.
- Overexpression of lnc-DILC significantly suppressed BC cell proliferation, metastasis, and CSC expansion.
- Inhibition of the STAT3 pathway by lnc-DILC was confirmed using a specific STAT3 inhibitor, which reversed the suppressive effects.
Conclusions:
- lnc-DILC functions as a novel tumor suppressor in bladder cancer.
- lnc-DILC inhibits BC progression and metastasis by inactivating the STAT3 signaling pathway.
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