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IGFBP1 Is a Predictive Factor for Haematogenous Metastasis in Patients With Gastric Cancer
Yuya Sato1, Mikito Inokuchi2, Yoko Takagi3
1Department of Gastric Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Background/Aim:
The clinicopathological significance and prognostic value of insulin-like growth factor binding protein 1 (IGFBP1) in gastric cancer have not been investigated to date. This study aimed to investigate the relationship of IGFBP1 expression with clinicopathological variables and prognosis.
Materials And Methods:
The correlation of IGFBP1 expression with the clinicopathological factors and the correlation of clinicopathogical factors with haematogenous metastasis in 219 gastric cancer patients who underwent surgery was examined.
Results:
High IGFBP1 expression was significantly associated with a poorer disease-specific survival (p<0.001) and relapse-free survival (p<0.001) in univariable analysis although IGFBP1 was not an independent prognostic factor. High IGFBP1 expression was the only independent risk factor of haematogenous metastasis.
Conclusion:
High IGFBP1 expression was associated with haematogenous metastasis and poor survival. IGFBP1 might become a new prognostic factor and a target of molecular targeted therapy of gastric cancer.
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