Related Experiment Video

Updated: Jan 23, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.7K

Optimal Timing of Cabazitaxel Introduction for Japanese Patients With Metastatic Castration-resistant Prostate Cancer

Toshiki Ito1, Kent Kanao2, Kiyoshi Takahara3

  • 1Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Anticancer Research
|June 10, 2019
PubMed
Abstract

Insights

For metastatic castration-resistant prostate cancer (mCRPC), a lower prostate-specific antigen (PSA) level at the start of cabazitaxel treatment may indicate optimal timing for improved overall survival (OS). This finding aids physicians in mCRPC treatment decisions.

Area of Science:

  • Oncology
  • Urology
  • Clinical Pharmacology

Background:

  • Limited guidance exists for initiating cabazitaxel in metastatic castration-resistant prostate cancer (mCRPC) patients post-docetaxel failure.
  • Optimal timing for cabazitaxel introduction remains an area requiring further clarification.

Purpose of the Study:

  • To evaluate the optimal timing for introducing cabazitaxel in mCRPC patients.
  • To identify predictors of overall survival (OS) following cabazitaxel initiation.

Main Methods:

  • Retrospective analysis of clinical outcomes in 66 mCRPC patients treated with cabazitaxel after docetaxel failure.
  • Assessment of various parameters, including prostate-specific antigen (PSA) levels, for their impact on OS.

Main Results:

  • An elevated PSA value from the diagnosis of castration-resistant prostate cancer (CRPC) significantly impacted OS after cabazitaxel introduction.
  • A strong correlation was observed between PSA increase from CRPC diagnosis and baseline PSA at cabazitaxel initiation.
  • Multivariate analysis identified baseline PSA at cabazitaxel introduction as an independent predictor of OS.

Conclusions:

  • A lower baseline PSA value at cabazitaxel introduction may serve as an indicator for optimal treatment timing.
  • This finding can assist clinicians in making informed decisions regarding cabazitaxel therapy for mCRPC.
Keywords:
Metastatic castration-resistant prostate cancercabazitaxeltiming

More Related Videos

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

7.2K
Murine Prostate Micro-dissection and Surgical Castration08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

47.6K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.4K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
5.7K
Optimal Foraging00:48

Optimal Foraging

How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
13.7K
Resistance and Conductance01:25

Resistance and Conductance

A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
498
Equivalent Resistance01:16

Equivalent Resistance

In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
947