Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation
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Fiammetta Monacelli1,2, Lucia Martella1,2, Maria Nives Parodi1,2
1Department of Internal Medicine and Medical Specialities, DIMI, Section of Geriatrics, Genoa, Italy.
Journal of Alzheimer'S Disease : JAD
|June 10, 2019
Abstract:
Alzheimer's disease may mimic frontotemporal dementia. We describe a case of presenile dementia who presented with peudo-psychotic symptoms carrying a PSEN1 mutation (P355 S), which was not known to be pathogenic. PET-FDG showed bilateral frontotemporal hypometabolism, but at MRI, multiple microbleeds were detected, suggestive of amyloid angiopathy.