Related Experiment Video

Updated: Jan 23, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.8K

[Clinical characteristics, treatment and outcome of chronic mercury-related nephrotic syndrome]

Z Z Gao1, X Q Du, X L Zhu

  • 1Department of Occupational Disease and Poisoning, Beijing Chaoyang Hospital Capital, Medical University, Beijing 100020, China.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases
|June 11, 2019
PubMed

Insights

Chronic mercury poisoning can cause nephrotic syndrome, often presenting with edema and proteinuria. Prompt mercury removal treatment leads to a high remission rate, with glucocorticoids beneficial in severe cases.

Area of Science:

  • Nephrology
  • Toxicology
  • Environmental Health

Background:

  • Nephrotic syndrome is a complex kidney disorder.
  • Chronic mercury poisoning is a potential, yet often overlooked, etiology.
  • Early identification and intervention are crucial for patient outcomes.

Purpose of the Study:

  • To elucidate the causes, clinical presentation, management strategies, and outcomes of nephrotic syndrome linked to chronic mercury exposure.
  • To analyze the effectiveness of mercury removal and adjunctive therapies.

Main Methods:

  • Retrospective analysis of 33 patients diagnosed with chronic mercury-induced nephrotic syndrome between June 2013 and April 2018.
  • Evaluation of clinical data, laboratory findings, treatment protocols, and patient outcomes.
  • Correlation analysis between urinary mercury levels and proteinuria.

Main Results:

  • The majority of cases (27/33) resulted from daily-life mercury exposure.
  • Typical nephrotic syndrome symptoms included lower extremity edema and proteinuria.
  • A 90.9% clinical remission rate was achieved, with mercury removal alone or combined with glucocorticoids and/or immunosuppressants.
  • Increased urinary mercury excretion correlated with a decrease in proteinuria (P<0.01).

Conclusions:

  • Chronic mercury-induced nephrotic syndrome often presents with non-specific symptoms, increasing the risk of misdiagnosis.
  • Mercury removal is the cornerstone of treatment.
  • The prognosis is generally favorable, with glucocorticoid therapy indicated for severe presentations.

Keywords:
Clinical featuresMercury poisoningNephrotic syndromeTreatment

More Related Videos

Transaxillary First Rib Resection for Treatment of the Thoracic Outlet Syndrome06:57

Transaxillary First Rib Resection for Treatment of the Thoracic Outlet Syndrome

Published on: September 13, 2020

4.0K
Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis02:15

Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis

Published on: March 1, 2024

863

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
531
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
216
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
293
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
376
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
590
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
745