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Updated: Jan 23, 2026

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
Diagnosis and Prognosis of Canine Cutaneous Mast Cell Tumors
1Michigan State University Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road, Room 152A, Lansing, MI 48910, USA; Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road, Room 152A, Lansing, MI 48910, USA.
Abstract:
Canine cutaneous mast cell tumors (MCTs) are among the most common canine cutaneous tumors, with highly variable biological behavior. This review describes in detail current approaches for cytologic and histologic diagnosis and prognosis, including advantages and limitations of cytologic and histologic grading and utilization of molecular markers, for example, Ki67, AgNORs, KIT expression, and c-Kit mutations, for a more accurate detection of aggressive MCTs. Furthermore, the current approach to evaluate surgical margins and spread to local lymph nodes is discussed.
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