Parental consanguinity in Hong Kong.
K H Siong1, S K C Au Yeung1, T Y Leung2
1Department of Obstetrics and Gynaecology, Tuen Mun Hospital, Tuen Mun, Hong Kong.
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi
|June 11, 2019
Summary
Parental consanguinity in Hong Kong, though rare, significantly elevates offspring risks for genetic disorders, congenital abnormalities, and developmental delays. Genetic counseling is crucial for informed decision-making in consanguineous unions.
Area of Science:
- Medical Genetics
- Reproductive Health
- Public Health
Background:
- Consanguineous unions increase the risk of genetic disorders in offspring.
- Understanding the prevalence and impact of consanguinity is vital for public health initiatives.
Purpose of the Study:
- To evaluate the prevalence and characteristics of parental consanguinity in Hong Kong.
- To assess the effects of consanguinity on pregnancy, perinatal, and child health outcomes.
Main Methods:
- Retrospective study of pregnant women in consanguineous unions versus non-consanguineous controls in Hong Kong.
- Comparison of pregnancy, perinatal, and child health outcomes between the two groups.
Main Results:
- Parental consanguinity prevalence was 0.6%, predominantly among ethnic Pakistanis.
- Consanguineous unions showed higher risks for congenital abnormalities, unexplained fetal/neonatal deaths, recessive diseases, structural abnormalities, developmental delay, and autistic spectrum disorder.
- Offspring of consanguineous parents had significantly higher odds for recessive diseases (OR=8.70), structural abnormalities (OR=4.55), and developmental delay (OR=6.72).
Conclusions:
- Genetic counseling for consanguineous couples must include information on increased health risks.
- Informed decision-making is essential for couples considering consanguineous unions.
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