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Multivariate surface-based analysis of corpus callosum in patients with sickle cell disease

Yaqiong Chai1,2,3, Yi Lao1,2,3, Yicen Li4

  • 1CIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.

Proceedings of Spie--The International Society for Optical Engineering
|June 11, 2019
PubMed

Insights

Sickle cell disease (SCD) patients show distinct corpus callosum (CC) shape differences. This study reveals new insights into brain structure alterations in SCD, potentially explaining cognitive impairments.

Area of Science:

  • Neurology
  • Radiology
  • Genetics

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder causing abnormal hemoglobin.
  • SCD increases the risk of cerebrovascular accidents and associated neurocognitive impairment.
  • The corpus callosum (CC), a major white matter tract, may reveal chronic cerebrovascular damage in SCD.

Purpose of the Study:

  • To investigate corpus callosum (CC) surface morphology in sickle cell disease (SCD) patients.
  • To identify regional shape differences in the CC using advanced morphometry techniques.
  • To explore the anatomical basis of neuropsychological differences in SCD.

Main Methods:

  • Surface morphometry analysis of the corpus callosum (CC).
  • Utilized four distinct shape metrics on T1-weighted MRI scans.
  • Compared CC morphology between 11 SCD patients and 10 healthy controls.

Main Results:

  • Detected significant regional surface morphological differences in the CC of SCD patients.
  • Observed alterations in the genu, posterior midbody, and splenium of the CC.
  • These findings represent the first surface morphometry analysis of the CC in SCD.

Conclusions:

  • Surface morphometry reveals specific CC shape alterations in SCD patients.
  • These morphological changes may underlie observed neuropsychological deficits.
  • This study provides novel anatomical insights into SCD-related brain changes.

Keywords:
corpus callosummultivariate tensor based morphometrysickle cell disease

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